Article
A mutation in a methionine tRNA gene suppresses the prp2-1 Ts mutation and causes a pre-mRNA splicing defect in Saccharomyces cerevisiae.
Genetics - 1 Nov 1999
Kim D H, Edwalds-Gilbert G, Ren C, Lin R J
Abstract excerpt
The PRP2 gene in Saccharomyces cerevisiae encodes an RNA-dependent ATPase that activates spliceosomes for the first transesterification reaction in pre-mRNA splicing. We have identified a mutation in the elongation methionine tRNA gene EMT1 as a dominant, allele-specific suppressor of the temperature-sensitive prp2-1 mutation. The EMT1-201 mutant suppressed prp2-1 by relieving the splicing block at high...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.