Article
A conditional knockout resource for the genome-wide study of mouse gene function.
Nature - 15 Jun 2011
Skarnes William C, Rosen Barry, West Anthony P, Koutsourakis Manousos, Bushell Wendy, Iyer Vivek, Mujica Alejandro O, Thomas Mark, Harrow Jennifer, Cox Tony, Jackson David, Severin Jessica, Biggs Patrick, Fu Jun, Nefedov Michael, de Jong Pieter J, Stewart A Francis, Bradley Allan
Abstract excerpt
Gene targeting in embryonic stem cells has become the principal technology for manipulation of the mouse genome, offering unrivalled accuracy in allele design and access to conditional mutagenesis. To bring these advantages to the wider research community, large-scale mouse knockout programmes are producing a permanent resource of targeted mutations in all protein-coding genes. Here we report the establishment of...
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