Article
Toll-like receptor 4 polymorphisms and the risk of gram-negative bacterial infections after liver transplantation.
Transplantation - 27 Sept 2011
Lee Sang-Oh, Brown Robert A, Kang Seung H, Abdel Massih Rima C, Razonable Raymund R
Abstract excerpt
BACKGROUND: Toll-like receptor 4 (TLR4) is the main immune molecule that recognizes lipopolysaccharide from gram-negative bacteria. Single-nucleotide polymorphisms (SNPs) in the TLR4 gene that impair lipopolysaccharide recognition may influence gram-negative bacterial infections after liver transplantation. METHODS: TLR4 D299G and T399I SNPs were assessed in a cohort of 706 liver transplant recipients and were...
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