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Article

A single nucleotide polymorphism of Toll-like receptor 4 identifies the risk of developing graft failure after liver transplantation.

Journal of hepatology - 1 Jul 2010

Dhillon Navdeep, Walsh Liron, Krüger Bernd, Ward Stephen C, Godbold James H, Radwan Mohamed, Schiano Thomas, Murphy Barbara T, Schröppel Bernd

Abstract excerpt

BACKGROUND & AIMS: While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to the pathophysiology of ischemia/reperfusion (IR) injury and liver fibrosis, the relevance of TLR4 activation after human liver transplantation is unknown. The TLR4 single nucleotide polymorphism (SNP) D299G is situated within the extracellular domain and diminishes receptor binding to danger-associated molecular...

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Source

Identifiers

PMID: 20400193
DOI: 10.1016/j.jhep.2009.12.044

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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