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Article

A data-driven method for identifying rare variants with heterogeneous trait effects.

Genetic epidemiology - 1 Nov 2011

Zhang Qunyuan, Irvin Marguerite R, Arnett Donna K, Province Michael A, Borecki Ingrid

Abstract excerpt

Collapsing multiple variants into one variable and testing their collective effect is a useful strategy for rare variant association analysis. Direct collapsing, however, is not valid or may significantly lose power when a group of variants to be collapsed have heterogeneous effects on target traits (i.e. some positive and some negative). This could be especially true for quantitative traits (such as blood...

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Identifiers

PMID: 21818776
DOI: 10.1002/gepi.20618
PMCID: PMC3201701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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