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Article

Pooled association tests for rare variants in exon-resequencing studies.

American journal of human genetics - 11 Jun 2010

Price Alkes L, Kryukov Gregory V, de Bakker Paul I W, Purcell Shaun M, Staples Jeff, Wei Lee-Jen, Sunyaev Shamil R

Abstract excerpt

Deep sequencing will soon generate comprehensive sequence information in large disease samples. Although the power to detect association with an individual rare variant is limited, pooling variants by gene or pathway into a composite test provides an alternative strategy for identifying susceptib...

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Identifiers

PMID: 20471002
DOI: 10.1016/j.ajhg.2010.04.005
PMCID: PMC3032073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20471002-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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