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Article

Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia.

PloS one - 1 Jan 2011

Takashima Noriko, Odaka Yuri S, Sakoori Kazuto, Akagi Takumi, Hashikawa Tsutomu, Morimura Naoko, Yamada Kazuyuki, Aruga Jun

Abstract excerpt

Recent genetic linkage analysis has shown that LRRTM1 (Leucine rich repeat transmembrane neuronal 1) is associated with schizophrenia. Here, we characterized Lrrtm1 knockout mice behaviorally and morphologically. Systematic behavioral analysis revealed reduced locomotor activity in the early dark phase, altered behavioral responses to novel environments (open-field box, light-dark box, elevated plus maze, and...

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Identifiers

PMID: 21818371
DOI: 10.1371/journal.pone.0022716
PMCID: PMC3144940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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