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Article

RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Apr 2010

Blundell Jacqueline, Kaeser Pascal S, Südhof Thomas C, Powell Craig M

Abstract excerpt

Several presynaptic proteins involved in neurotransmitter release in the CNS have been implicated in schizophrenia in human clinical genetic studies, in postmortem studies, and in studies of putative animal models of schizophrenia. The presynaptic protein RIM1alpha mediates presynaptic plasticity and cognitive function. We now demonstrate that mice deficient in RIM1alpha exhibit abnormalities in multiple...

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Identifiers

PMID: 20392954
DOI: 10.1523/JNEUROSCI.0328-10.2010
PMCID: PMC2860606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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