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Article

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic.

Cell - 29 Jul 1994

Nellen D, Affolter M, Basler K

Abstract excerpt

Members of the TGF beta superfamily of secreted signaling molecules regulate growth and cellular patterning during development and interact with specific type I and type II membrane receptors possessing a cytoplasmic serine/threonine kinase domain. We describe two members of the type I receptor family in Drosophila and demonstrate that they are encoded by the genes saxophone (sax) and thick veins (tkv). Further,...

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Identifiers

PMID: 8044837
DOI: 10.1016/0092-8674(94)90293-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic.PMID 8044837Read ↗

Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis.Semantic proximity Read ↗

Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila.Semantic proximity Read ↗

The Drosophila saxophone gene: a serine-threonine kinase receptor of the TGF-beta superfamily.Semantic proximity Read ↗

An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo.Semantic proximity Read ↗

The interaction between two TGF-beta type I receptors plays important roles in ligand binding, SMAD activation, and gradient formation.Semantic proximity Read ↗

Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins.Semantic proximity Read ↗

Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing.Semantic proximity Read ↗

Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVRL1 and ACVR1/ALK2.Semantic proximity Read ↗

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor.Semantic proximity Read ↗

Analysis of the shortvein cis-regulatory region of the decapentaplegic gene of Drosophila melanogaster.Semantic proximity Read ↗

The thick veins gene of Drosophila is required for dorsoventral polarity of the embryo.Semantic proximity Read ↗

Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila.Semantic proximity Read ↗

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