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Article

Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker.

Cell - 19 Feb 1999

Campbell G, Tomlinson A

Abstract excerpt

Dpp, a TGFbeta, organizes pattern in the Drosophila wing by acting as a graded morphogen, activating different targets above distinct threshold concentrations. Like other TGFbetas, Dpp appears to induce transcription directly via activation of a SMAD, Mad. However, here we demonstrate that Dpp can also control gene expression indirectly by downregulating the expression of the brinker gene, which encodes a...

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Source

Identifiers

PMID: 10052457
DOI: 10.1016/s0092-8674(00)80659-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker.PMID 10052457Read ↗

The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation.Semantic proximity Read ↗

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.Semantic proximity Read ↗

The role of brinker in mediating the graded response to Dpp in early Drosophila embryos.Semantic proximity Read ↗

Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription.Semantic proximity Read ↗

Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker.Semantic proximity Read ↗

Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels.Semantic proximity Read ↗

Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye.Semantic proximity Read ↗

The role of brinker in eggshell patterning.Semantic proximity Read ↗

Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.Semantic proximity Read ↗

Dpp and Gbb exhibit different effective ranges in the establishment of the BMP activity gradient critical for Drosophila wing patterning.Semantic proximity Read ↗

An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo.Semantic proximity Read ↗

A simple molecular complex mediates widespread BMP-induced repression during Drosophila development.Semantic proximity Read ↗

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