Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pancreatic β Cell-specific Transcription of thepdx-1 Gene

1 Feb 2000

Abstract excerpt

To identify potential transactivators of pdx-1, we sequenced approximately 4.5 kilobases of the 5' promoter region of the human and chicken homologs, assuming that sequences conserved with the mouse gene would contain critical cis-regulatory elements. The sequences associated with hypersensitive site 1 (HSS1) represented the principal area of homology within which three conserved subdomains were apparent: area I...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Genetics and Neurodevelopmental Disorders
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10652343
DOI: 10.1074/jbc.275.5.3485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pancreatic β Cell-specific Transcription of thepdx-1 GenePMID 10652343Read ↗

Conserved Transcriptional Regulatory Domains of the pdx-1 GeneSemantic proximity Read ↗

Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6.Semantic proximity Read ↗

Regulation of pdx-1 Gene ExpressionSemantic proximity Read ↗

A Pancreatic β-Cell-specific Enhancer in the HumanPDX-1 Gene Is Regulated by Hepatocyte Nuclear Factor 3β (HNF-3β), HNF-1α, and SPs Transcription FactorsSemantic proximity Read ↗

Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.Semantic proximity Read ↗

Identification of cis- and trans-Active Factors Regulating Human Islet Amyloid Polypeptide Gene Expression in Pancreatic β-CellsSemantic proximity Read ↗

Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific ExpressionSemantic proximity Read ↗

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in miceSemantic proximity Read ↗

Transcription Factors in Islet Development and Physiology: Role of PDX‐1 in Beta‐Cell FunctionSemantic proximity Read ↗

Autoregulation and Maturity Onset Diabetes of the Young Transcription Factors Control the Human PAX4 PromoterSemantic proximity Read ↗

Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.Semantic proximity Read ↗

FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start SiteSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.