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Article

Genetic variation in the tau kinases pathway may modify the risk and age at onset of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Vázquez-Higuera José Luis, Mateo Ignacio, Sánchez-Juan Pascual, Rodríguez-Rodríguez Eloy, Pozueta Ana, Calero Miguel, Dobato José Luis, Frank-García Ana, Valdivieso Fernando, Berciano José, Bullido Maria J, Combarros Onofre

Abstract excerpt

Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in the Alzheimer's disease (AD) brain is the result of upregulation of tau kinases. In a group of 729 Spanish late-onset AD patients and 670 healthy controls, we examined variations into a set of 20 candidate genes of kinases involved in tau phosphorylation at AD-related sites (PRKACB; CAMK2A; MARK1, 2, 3 and 4; CSNK1D; CDC2; RPS6KB1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21811019
DOI: 10.3233/JAD-2011-110794

Genes

APOE
MARK1
PRKACB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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