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Article

The Association of Selected GWAS Reported AD Risk Loci with CSF Biomarker Levels and Cognitive Decline in Slovenian Patients.

International journal of molecular sciences - 19 Aug 2023

Vogrinc David, Gregorič Kramberger Milica, Emeršič Andreja, Čučnik Saša, Goričar Katja, Dolžan Vita

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disease, with a complex genetic background. Apart from rare, familial cases, a combination of multiple risk loci contributes to the susceptibility of the disease. Genome-wide association studies (GWAS) have identified numerous AD risk loci. Changes in cerebrospinal fluid (CSF) biomarkers and imaging techniques can detect AD-related brain changes before...

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PMID: 37629144
DOI: 10.3390/ijms241612966
PMCID: PMC10455613

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