Article
Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk.
Neurobiology of aging - 1 Feb 2009
Rodríguez-Rodríguez Eloy, Infante Jon, Llorca Javier, Mateo Ignacio, Sánchez-Quintana Coro, García-Gorostiaga Inés, Sánchez-Juan Pascual, Berciano José, Combarros Onofre
Abstract excerpt
An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR...
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