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Article

Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2012

Bekris Lynn M, Millard Steve, Lutz Franziska, Li Gail, Galasko Doug R, Farlow Martin R, Quinn Joseph F, Kaye Jeffrey A, Leverenz James B, Tsuang Debby W, Yu Chang-En, Peskind Elaine R

Abstract excerpt

Alzheimer's disease (AD) is characterized by the presence in the brain of amyloid plaques, consisting predominately of the amyloid β peptide (Aβ), and neurofibrillary tangles, consisting primarily of tau. Hyper-phosphorylated-tau (p-tau) contributes to neuronal damage, and both p-tau and total-tau (t-tau) levels are elevated in AD cerebrospinal fluid (CSF) compared to cognitively normal controls. Our hypothesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22927204
DOI: 10.1002/ajmg.b.32094
PMCID: PMC3626266

Genes

FYN
MAPT

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