Article
Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.
BMC genomics - 3 Aug 2011
Mok Sachel, Imwong Mallika, Mackinnon Margaret J, Sim Joan, Ramadoss Ramya, Yi Poravuth, Mayxay Mayfong, Chotivanich Kesinee, Liong Kek-Yee, Russell Bruce, Socheat Duong, Newton Paul N, Day Nicholas P J, White Nicholas J, Preiser Peter R, Nosten François, Dondorp Arjen M, Bozdech Zbynek
Abstract excerpt
BACKGROUND: Artemisinin resistance in Plasmodium falciparum malaria has emerged in Western Cambodia. This is a major threat to global plans to control and eliminate malaria as the artemisinins are a key component of antimalarial treatment throughout the world. To identify key features associated with the delayed parasite clearance phenotype, we employed DNA microarrays to profile the physiological gene expression...
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