Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates

20 Nov 2008

Abstract excerpt

Genome sequences of Plasmodium falciparum allow for global analysis of drug responses to antimalarial agents. It was of interest to learn how DNA microarrays may be used to study drug action in malaria parasites. In one large, tightly controlled study involving 123 microarray hybridizations between cDNA from isogenic drug-sensitive and drug-resistant parasites, a lethal antifolate (WR99210) failed to over-produce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19023412
DOI: 10.1371/journal.ppat.1000214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal AntifolatesPMID 19023412Read ↗

Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparumSemantic proximity Read ↗

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.Semantic proximity Read ↗

Using the genome to dissect the molecular basis of drug resistance.Semantic proximity Read ↗

Divergent Regulation of Dihydrofolate Reductase Between Malaria Parasite and Human HostSemantic proximity Read ↗

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.Semantic proximity Read ↗

Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays.Semantic proximity Read ↗

Dihydroartemisinin induces a two-step transcriptional response and stage-specific developmental shifts in malaria parasites, <i>Plasmodium falciparum</i>Semantic proximity Read ↗

Regulatory hotspots in the malaria parasite genome dictate transcriptional variation.Semantic proximity Read ↗

How genomics is contributing to the fight against artemisinin-resistant malaria parasitesSemantic proximity Read ↗

Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistanceSemantic proximity Read ↗

A system-level gene regulatory network model for <i>Plasmodium falciparum</i>Semantic proximity Read ↗

Novel <i>Plasmodium falciparum</i> metabolic network reconstruction identifies shifts associated with clinical antimalarial resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.