Article
The role of TNF and its family members in inflammation and cancer: lessons from gene deletion.
Current drug targets. Inflammation and allergy - 1 Dec 2002
Aggarwal Bharat B, Shishodia Shishir, Ashikawa Kazuhiro, Bharti Alok C
Abstract excerpt
Almost two decades ago, tumor necrosis factor (TNF) was identified as a protein produced by the immune system that played a major role in suppression of tumor cell proliferation. Extensive research since then has revealed that TNF is a major mediator of inflammation, viral replication, tumor metastasis, transplant rejection, rheumatoid arthritis, and septic shock. As of today, 18 different members of the TNF...
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