Early influence of the rs4675690 on the neural substrates of sadness.

doi:10.1016/j.jad.2011.06.039

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Article

Early influence of the rs4675690 on the neural substrates of sadness.

Journal of affective disorders - 1 Dec 2011

Fortier Emilie, Noreau Anne, Lepore Franco, Boivin Michel, Pérusse Daniel, Rouleau Guy A, Beauregard Mario

Abstract excerpt

BACKGROUND: CREB1 has previously been implicated in mood disorders, suicide, and antidepressant response. There is some evidence that the T allele in rs4675690, a single-nucleotide polymorphism near the CREB1 gene, is involved in the modulation of neural responses to negative stimuli. It is not known whether differential brain activity during negative mood state appears early in life in T allele carriers....

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PMID: 21807415
DOI: 10.1016/j.jad.2011.06.039

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