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Article

Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function.

Genes, brain, and behavior - 1 Apr 2012

Wang L, Ashley-Koch A, Steffens D C, Krishnan K R R, Taylor W D

Abstract excerpt

The brain-derived neurotrophic factor (BDNF) Val(66) Met allelic variation is linked to both the occurrence of mood disorders and antidepressant response. These findings are not universally observed, and the mechanism by which this variation results in increased risk for mood disorders is unclear. One possible explanation is an epistatic relationship with other neurotransmitter genes associated with depression...

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Source

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Identifiers

PMID: 22225729
DOI: 10.1111/j.1601-183X.2012.00764.x
PMCID: PMC3654542

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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