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Article

Inducing high rates of targeted mutagenesis in zebrafish using zinc finger nucleases (ZFNs).

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

McCammon Jasmine M, Doyon Yannick, Amacher Sharon L

Abstract excerpt

Animal models, including the zebrafish, without a reliable embryonic stem cell system are not easily amenable to targeted mutagenesis for studying gene function. Three recent publications have shown that zinc finger nucleases (ZFNs) have circumvented this shortcoming in zebrafish. Similar to restriction enzymes, ZFNs can introduce site-specific double-strand breaks (DSBs); moreover, they can be designed to...

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PMID: 21805278
DOI: 10.1007/978-1-61779-210-6_20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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