Article

De-biased sparse canonical correlation for identifying cancer-related trans-regulated genes

2024-08-19

Abstract excerpt

<h4> S ummary </h4> In cancer multi-omic studies, identifying the effects of somatic copy number aberrations (CNA) on physically distal gene expressions (trans-associations) can potentially uncover genes critical for cancer pathogenesis. Sparse canonical correlation analysis (SCCA) has emerged as a promising method for identifying associations in high-dimensional settings, owing to its ability to aggregate weak...

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Literature Corpus work: 9dbd0f5a-de4f-538c-a363-a004c1cab34d
DOI: 10.1101/2024.08.15.608166

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