Article
Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy.
Oncogene - 10 Feb 2011
Tommasi S, Besaratinia A, Wilczynski S P, Pfeifer G P
Abstract excerpt
Loss of RASSF1A leads to several mitotic abnormalities, including cytokinesis failure and tetraploidization. Uncontrolled proliferation of tetraploid cells is known to trigger genomic instability and tumor development and is normally prevented through activation of a p53-dependent tetraploidy checkpoint. RASSF1A is the most commonly silenced and p53 is the most frequently mutated tumor suppressor gene in human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.