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Article

Inferring gene-phenotype associations via global protein complex network propagation.

PloS one - 1 Jan 2011

Yang Peng, Li Xiaoli, Wu Min, Kwoh Chee-Keong, Ng See-Kiong

Abstract excerpt

BACKGROUND: Phenotypically similar diseases have been found to be caused by functionally related genes, suggesting a modular organization of the genetic landscape of human diseases that mirrors the modularity observed in biological interaction networks. Protein complexes, as molecular machines that integrate multiple gene products to perform biological functions, express the underlying modular organization of...

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PMID: 21799737
DOI: 10.1371/journal.pone.0021502
PMCID: PMC3143124

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