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Inferring disease and gene set associations with rank coherence in networks.

Bioinformatics (Oxford, England) - 1 Oct 2011

Hwang TaeHyun, Zhang Wei, Xie Maoqiang, Liu Jinfeng, Kuang Rui

Abstract excerpt

MOTIVATION: To validate the candidate disease genes identified from high-throughput genomic studies, a necessary step is to elucidate the associations between the set of candidate genes and disease phenotypes. The conventional gene set enrichment analysis often fails to reveal associations between disease phenotypes and the gene sets with a short list of poorly annotated genes, because the existing annotations of...

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PMID: 21824970
DOI: 10.1093/bioinformatics/btr463

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