Article

Leveraging protein-protein interactions in phenotype prediction through graph neural networks

2024-08-16

Abstract excerpt

Current genotype-to-phenotype models, such as poly-genic risk scores, only account for linear relationships between genotype and phenotype and ignore epistatic interactions, limiting the complexity of the diseases that can be properly characterized. Protein-protein interaction networks have the potential to improve the performance of the models. Moreover, interactions at the protein level can have profound implica...

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Literature Corpus work: 445d06e5-f195-5f62-93bd-3e1cdf3540a6
DOI: 10.1101/2024.08.13.605573

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