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Article

Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2011

Flachsbart Friederike, Ufer Mike, Kleindorp Rabea, Nikolaus Susanna, Schreiber Stefan, Nebel Almut

Abstract excerpt

Cytochrome P450 enzymes, especially the CYP2C subfamily, are involved in the generation of reactive oxygen species and are regarded as susceptibility factors for age-related diseases. Furthermore, the CYP2C-encoding genes are known to be highly polymorphic, with a number of variants leading to changes in enzyme activity. These observations prompted us to investigate whether allelic variation in the CYP2C-encoding...

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Identifiers

PMID: 21798861
DOI: 10.1093/gerona/glr117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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