Article
Cytochrome P450 2J2 polymorphism in healthy Caucasians and those with diabetes mellitus.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2003
Pucci Laura, Lucchesi Daniela, Chirulli Vera, Penno Giuseppe, Johansson Inger, Gervasi Pier, Del Prato Stefano, Longo Vincenzo
Abstract excerpt
OBJECTIVE: Cytochrome P450 (CYP) 2J2 plays an important role in the biosynthesis of the biologically active cis-epoxyeicosatrienoic acids. An allelic variant named CYP2J2*6, which encodes an enzyme that is almost inactive in the metabolism of arachidonic acid, has recently been described. We investigated the frequency of the CYP2J2*6 variant in a Caucasian population and the relationship between this polymorphism...
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