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Article

Smad phosphoisoform signaling specificity: the right place at the right time

27 Jul 2011

Abstract excerpt

Transforming growth factor (TGF)-β antagonizes mitogenic Ras signaling during epithelial regeneration, but TGF-β and Ras act synergistically in driving tumor progression. Insights into these apparently contradictory effects have come from recent detailed analyses of the TGF-β signaling process. Here, we summarize the different modes of TGF-β/Ras signaling in normal epithelium and neoplasms and show how...

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PMID: 21798854
DOI: 10.1093/carcin/bgr172

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