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Article

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

25 May 2018

Abstract excerpt

The multi-functional cytokine transforming growth factor-β1 (TGF-β1) has growth inhibitory and anti-inflammatory roles during homeostasis and the early stages of cancer. Aberrant TGF-β activation in the late-stages of tumorigenesis, however, promotes development of aggressive growth characteristics and metastatic spread. Given the critical importance of this growth factor in fibrotic and neoplastic disorders, the...

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PMID: 29799477
DOI: 10.3390/cancers10060159

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