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Article

Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma.

Haematologica - 1 Nov 2011

Kleppe Maria, Tousseyn Thomas, Geissinger Eva, Kalender Atak Zeynep, Aerts Stein, Rosenwald Andreas, Wlodarska Iwona, Cools Jan

Abstract excerpt

We recently reported deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Functional analyses confirmed that PTPN2 acts as classical tumor suppressor repressing the proliferation of T cells, in part through inhibition of JAK/STAT signaling. We investigated the expression of PTPN2 in leukemia as well as lymphoma cell lines. We identified bi-allelic inactivation of PTPN2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

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Source

Open in PubMed Open full text

Identifiers

PMID: 21791476
DOI: 10.3324/haematol.2011.041921
PMCID: PMC3208694

Genes

PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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