Article
Identification of substrates of human protein-tyrosine phosphatase PTPN22.
The Journal of biological chemistry - 21 Apr 2006
Wu Jiansheng, Katrekar Anjali, Honigberg Lee A, Smith Ashley M, Conn Marion T, Tang Jie, Jeffery Doug, Mortara Kyle, Sampang Jun, Williams Steve R, Buggy Joseph, Clark James M
Abstract excerpt
Stimulation of mature T cells activates a downstream signaling cascade involving temporally and spatially regulated phosphorylation and dephosphorylation events mediated by protein-tyrosine kinases and phosphatases, respectively. PTPN22 (Lyp), a non-receptor protein-tyrosine phosphatase, is expressed exclusively in cells of hematopoietic origin, notably in T cells where it represses signaling through the T cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.