Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.

doi:10.1016/j.cell.2011.02.003

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Article

Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.

Cell - 4 Mar 2011

Sun Tingting, Aceto Nicola, Meerbrey Kristen L, Kessler Jessica D, Zhou Chunshui, Migliaccio Ilenia, Nguyen Don X, Pavlova Natalya N, Botero Maria, Huang Jian, Bernardi Ronald J, Schmitt Earlene, Hu Guang, Li Mamie Z, Dephoure Noah, Gygi Steven P, Rao Mitchell, Creighton Chad J, Hilsenbeck Susan G, Shaw Chad A, Muzny Donna, Gibbs Richard A, Wheeler David A, Osborne C Kent, Schiff Rachel, Bentires-Alj Mohamed, Elledge Stephen J, Westbrook Thomas F

Abstract excerpt

Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted therapies. Using a genetic screen, we identify the PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently suppresses mammary epithelial cell proliferation and transformation. PTPN12 is frequently compromised in human TNBCs, and we identify an upstream tumor-suppressor...

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Identifiers

PMID: 21376233
DOI: 10.1016/j.cell.2011.02.003
PMCID: PMC6014607

Genes

PTPN12
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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