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Article

High-resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to Non-Hodgkin's lymphoma.

Genes, chromosomes & cancer - 1 May 2013

Aya-Bonilla Carlos, Green Michael R, Camilleri Emily, Benton Miles, Keane Colm, Marlton Paula, Lea Rod, Gandhi Maher K, Griffiths Lyn R

Abstract excerpt

We employed a Hidden-Markov-Model (HMM) algorithm in loss of heterozygosity (LOH) analysis of high-density single nucleotide polymorphism (SNP) array data from Non-Hodgkin's lymphoma (NHL) entities, follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). This revealed a high frequency of LOH over the chromosomal region 11p11.2, containing the gene encoding the protein tyrosine phosphatase receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23341091
DOI: 10.1002/gcc.22044

Genes

PTPRJ
BCR

Variants

rs2270993
rs2270993
rs2270993
rs2270993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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