Article
Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies.
Molecular cancer therapeutics - 1 Sept 2013
Yu Bing, Liu Wei, Yu Wen-Mei, Loh Mignon L, Alter Shawn, Guvench Olgun, Mackerell Alexander D, Tang Li-Da, Qu Cheng-Kui
Abstract excerpt
Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine signaling, are directly associated with the pathogenesis of Noonan syndrome and childhood leukemias. Identification of SHP2-selective inhibitors could lead to the development of new drugs that ultimately serve as treatments for PTPN11-associated diseases. As the...
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