Article
Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma.
Cancer science - 1 May 2009
Lee Suk-young, Kumano Keiki, Nakazaki Kumi, Sanada Masashi, Matsumoto Akihiko, Yamamoto Go, Nannya Yasuhito, Suzuki Ritsuro, Ota Satoshi, Ota Yasunori, Izutsu Koji, Sakata-Yanagimoto Mamiko, Hangaishi Akira, Yagita Hideo, Fukayama Masashi, Seto Masao, Kurokawa Mineo, Ogawa Seishi, Chiba Shigeru
Abstract excerpt
Signaling through the Notch1 receptor has a pivotal role in early thymocyte development. Gain of Notch1 function results in the development of T-cell acute lymphoblastic leukemia in a number of mouse experimental models, and activating Notch1 mutations deregulate Notch1 signaling in the majority of human T-cell acute lymphoblastic leukemias. Notch2, another member of the Notch gene family, is preferentially...
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