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Article

The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype

25 Apr 2019

Abstract excerpt

PURPOSE: The protein tyrosine phosphatase PTPN2 dephosphorylates several tyrosine kinases in cancer-related signalling pathways and is thought to be a tumour suppressor. As PTPN2 is not frequently studied in breast cancer, we aimed to explore the role of PTPN2 and the effects of its loss in breast cancer. METHODS: Protein expression and gene copy number of PTPN2 were analysed in a cohort of pre-menopausal breast...

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PMID: 31025094
DOI: 10.1007/s00432-019-02918-y

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