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Article

PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia

7 May 2011

Abstract excerpt

We have recently reported inactivation of the tyrosine phosphatase PTPN2 (also known as TC-PTP) through deletion of the entire gene locus in ∼ 6% of T-cell acute lymphoblastic leukemia (T-ALL) cases. T-ALL is an aggressive disease of the thymocytes characterized by the stepwise accumulation of chromosomal abnormalities and gene mutations. In the present study, we confirmed the strong association of the PTPN2...

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Identifiers

PMID: 21551237
DOI: 10.1182/blood-2010-10-314286

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