Article
The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.
PloS one - 1 Jan 2011
Min Josine L, Taylor Jennifer M, Richards J Brent, Watts Tim, Pettersson Fredrik H, Broxholme John, Ahmadi Kourosh R, Surdulescu Gabriela L, Lowy Ernesto, Gieger Christian, Newton-Cheh Chris, Perola Markus, Soranzo Nicole, Surakka Ida, Lindgren Cecilia M, Ragoussis Jiannis, Morris Andrew P, Cardon Lon R, Spector Tim D, Zondervan Krina T
Abstract excerpt
The integrated analysis of genotypic and expression data for association with complex traits could identify novel genetic pathways involved in complex traits. We profiled 19,573 expression probes in Epstein-Barr virus-transformed lymphoblastoid cell lines (LCLs) from 299 twins and correlated these with 44 quantitative traits (QTs). For 939 expressed probes correlating with more than one QT, we investigated the...
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