Article
A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes.
Clinical pharmacology and therapeutics - 1 Jun 2020
Etheridge Amy S, Gallins Paul J, Jima Dereje, Broadaway K Alaine, Ratain Mark J, Schuetz Erin, Schadt Eric, Schroder Adrian, Molony Cliona, Zhou Yihui, Mohlke Karen L, Wright Fred A, Innocenti Federico
Abstract excerpt
Expression quantitative trait locus (eQTL) studies in human liver are crucial for elucidating how genetic variation influences variability in disease risk and therapeutic outcomes and may help guide strategies to obtain maximal efficacy and safety of clinical interventions. Associations between expression microarray and genome-wide genotype data from four human liver eQTL studies (n = 1,183) were analyzed. More...
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