Article
Multivariate eQTL mapping uncovers functional variation on the X-chromosome associated with complex disease traits.
Human genetics - 1 Jul 2016
Brumpton Ben M, Ferreira Manuel A R
Abstract excerpt
Very few studies have investigated the associations between genetic polymorphisms and gene expression on the X-chromosome. This is a major bottleneck when conducting functional follow-up studies of trait-associated variants, as those identified in genome-wide association studies (GWAS). We used a multivariate approach to test the association between individual single nucleotide polymorphisms (SNPs) and exon...
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