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Article

In vitro selection of variants resistant to beta-lactams plus beta-lactamase inhibitors in CTX-M beta-lactamases: predicting the in vivo scenario?

Antimicrobial agents and chemotherapy - 1 Oct 2011

Ripoll Aida, Baquero Fernando, Novais Angela, Rodríguez-Domínguez Mario J, Turrientes Maria-Carmen, Cantón Rafael, Galán Juan-Carlos

Abstract excerpt

CTX-M β-lactamases are the most prevalent group of enzymes within the extended-spectrum β-lactamases (ESBL). The therapeutic options for CTX-M-carrying isolates are scarce, forcing the reexamination of the therapeutic possibilities of β-lactams plus β-lactamase inhibitors (BBLIs). Inhibitor-resistant CTX-M β-lactamases (IR-CTX-M) have not hitherto been described in natural isolates. In this study, 168 cultures of...

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Identifiers

PMID: 21788458
DOI: 10.1128/AAC.00178-11
PMCID: PMC3186957

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