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In Vitro Prediction of the Evolution of GES-1 β-Lactamase Hydrolytic Activity

6 Jan 2015

Abstract excerpt

Resistance to β-lactams is constantly increasing due to the emergence of totally new enzymes but also to the evolution of preexisting β-lactamases. GES-1 is a clinically relevant extended-spectrum β-lactamase (ESBL) that hydrolyzes penicillins and broad-spectrum cephalosporins but spares monobactams and carbapenems. However, several GES-1 variants (i.e., GES-2 and GES-5) previously identified among clinical...

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PMID: 25561336
DOI: 10.1128/aac.04450-14

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