Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical emergence of a novel extended-spectrum variant deriving from the OXY-1 β-lactamase.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Nov 2024

Hong Tuan Ha Anne-Sophie, Mammeri Alice, Plainvert Céline, Charfi Rym, Poyart Claire, Tazi Asmaa, Mammeri Hedi

Abstract excerpt

The genomic comparison of two Klebsiella michiganensis clinical isolates recovered from the same patient, one resistant to piperacillin-tazobactam and intermediate to cefotaxime, the other resistant to ceftazidime but susceptible to piperacillin-tazobactam, revealed one mutation in the blaOXY-1-24 gene accounting for a L169M substitution in the Ω loop. Cloning experiment in Escherichia coli demonstrated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to beta-Lactamases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ceftazidime

Share to Drug Resistance, Multiple, Bacterial

Share to Escherichia coli

Share to Klebsiella

Share to Klebsiella Infections

Share to Microbial Sensitivity Tests

Source

Identifiers

PMID: 39172287
DOI: 10.1007/s10096-024-04922-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical emergence of a novel extended-spectrum variant deriving from the OXY-1 β-lactamase.PMID 39172287Read ↗

Unveiling the evolution routes of TEM-type extended-spectrum β-lactamases.Semantic proximity Read ↗

Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.Semantic proximity Read ↗

Dissemination of clinical isolates of Klebsiella oxytoca harboring CMY-31, VIM-1, and a New OXY-2-type variant in the community.Semantic proximity Read ↗

Ceftazidime-resistant Klebsiella oxytoca producing an OXY-2-type variant from Switzerland.Semantic proximity Read ↗

Growing Group of Extended-Spectrum β-Lactamases: the CTX-M EnzymesSemantic proximity Read ↗

A triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis.Semantic proximity Read ↗

In Vitro Prediction of the Evolution of GES-1 β-Lactamase Hydrolytic ActivitySemantic proximity Read ↗

Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1.Semantic proximity Read ↗

In vitro selection of variants resistant to beta-lactams plus beta-lactamase inhibitors in CTX-M beta-lactamases: predicting the in vivo scenario?Semantic proximity Read ↗

FIM-1, a New Acquired Metallo-β-Lactamase from a Pseudomonas aeruginosa Clinical Isolate from ItalySemantic proximity Read ↗

Inhibitor-resistant OXY-2-derived beta-lactamase produced by Klebsiella oxytoca.Semantic proximity Read ↗

Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.