Article
Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains.
Antimicrobial agents and chemotherapy - 1 Apr 2008
Stepanova Marina N, Pimkin Maxim, Nikulin Anatoly A, Kozyreva Varvara K, Agapova Elena D, Edelstein Mikhail V
Abstract excerpt
We report on a novel CTX-M extended-spectrum beta-lactamase (ESBL), designated CTX-M-42, with enhanced activity toward ceftazidime. CTX-M-42 was identified in a hypermutable Escherichia coli nosocomial isolate (isolate Irk2320) and is a Pro167Thr amino acid substitution variant of CTX-M-3. By molecular typing of ESBL-producing E. coli strains previously isolated in the same hospital ward, we were able to identify...
Topics
- Anti-Bacterial Agents
- Ceftazidime
- Cephalosporin Resistance
- Directed Molecular Evolution
- Escherichia coli
- Escherichia coli Proteins
- Evolution, Molecular
- Humans
- Microbial Sensitivity Tests