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Article

Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.

FEMS microbiology reviews - 1 Nov 2010

Salverda Merijn L M, De Visser J Arjan G M, Barlow Miriam

Abstract excerpt

TEM-1 β-lactamase is one of the most well-known antibiotic resistance determinants around. It confers resistance to penicillins and early cephalosporins and has shown an astonishing functional plasticity in response to the introduction of novel drugs derived from these antibiotics. Since its discovery in the 1960s, over 170 variants of TEM-1 - with different amino acid sequences and often resistance phenotypes -...

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Identifiers

PMID: 20412308
DOI: 10.1111/j.1574-6976.2010.00222.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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