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Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance.

Antimicrobial agents and chemotherapy - 1 Jul 2008

Novais Angela, Cantón Rafael, Coque Teresa M, Moya Andrés, Baquero Fernando, Galán Juan Carlos

Abstract excerpt

CTX-M beta-lactamases, which show a high cefotaxime hydrolytic activity, constitute the most prevalent extended-spectrum beta-lactamase (ESBL) type found among clinical isolates. The recent explosive diversification of CTX-M enzymes seems to have taken place due to the appearance of more efficient enzymes which are capable of hydrolyzing both cefotaxime and ceftazidime, especially among the CTX-M-1 cluster. A...

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Identifiers

PMID: 18443114
DOI: 10.1128/AAC.01658-07
PMCID: PMC2443914

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Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance.PMID 18443114Read ↗

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