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Article

Mutations in V84I & A184V of blaTEM cluster plays a pivotal role in the dynamics of Ω-loop leading to genesis of IR-TEM.

Journal of biomolecular structure & dynamics - 1 Feb 2025

Banerjee Devjani, Rath Soumya Lipsa, Darji Siddhi A, Mandal Nabanita

Abstract excerpt

The Enterobacteriaceae family exhibits resistance to antibiotics by producing β-Lactamase. Mutations in β-Lactamase, have led to the generation of inhibitor resistant variants known as IR-TEM. In the present study, IR-TEM β-Lactamase of Enterobacter hormaechei and Enterobacter asburiae was compared. To investigate the mechanism behind the conferred mutation, we studied its interaction with Clavulanic acid,...

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Identifiers

PMID: 38063029
DOI: 10.1080/07391102.2023.2291168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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