Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.

doi:10.1016/s1074-7613(00)80595-6

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Article

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.

Immunity - 1 Jul 1998

Rada C, Ehrenstein M R, Neuberger M S, Milstein C

Abstract excerpt

Likely creation of mismatches during somatic hypermutation has stimulated interest in the effect of mismatch repair deficiency on the process. Analysis of unselected mutations in the 3' flank of VH rearrangements in germinal center B cells revealed that MSH2 deficiency caused a 5-fold reduced mut...

Topics

Animals
B-Lymphocytes
Binding Sites
Cell Line
DNA-Binding Proteins
Female
Genes, Immunoglobulin
Immunoglobulin Heavy Chains
Male
Mice
Mice, Knockout
MutS Homolog 2 Protein
Mutation
Proto-Oncogene Proteins

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