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Article

Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice

1 Feb 1999

Abstract excerpt

Recently, results obtained from mice with targeted inactivations of postreplication DNA mismatch repair (MMR) genes have been interpreted to demonstrate a direct role for MMR in antibody variable (V) gene hypermutation. Here we show that mice that do not express the MMR factor Msh2 have wide-ranging defects in antigen-driven B cell responses. These include lack of progression of the germinal center (GC) reaction...

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PMID: 9927509
DOI: 10.1084/jem.189.3.471

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Severe Attenuation of the B Cell Immune Response in Msh2-deficient MicePMID 9927509Read ↗

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MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.Semantic proximity Read ↗

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